Collagen Type II

Reviewed on 6/11/2021
Other Name(s):

Chicken Collagen Type II, Chicken Type II Collagen, Colágeno de Pollo, Collagen II, Collagen Type II, Collagène de Poulet, Collagène de Type II, Collagène de Type II de Cartilage de Poulet, Collagène de Type II Hydrolysé, Hydrolyzed Chicken Collagen Type II, Hydrolyzed Collagen Type II, Type II Collagen.


Collagen is a protein that is part of cartilage, bone, and other tissues in animals and humans. People use collagen from chickens for medicine.

Chicken collagen is used to treat joint pain associated with many types of arthritis and surgery, as well as back pain, neck pain, and pain following injury.

How does it work?

Chicken collagen is said to work by causing the body to produce substances that fight pain and swelling (inflammation), but this is unproven. Chicken collagen also contains the chemicals chondroitin and glucosamine, which might help rebuild cartilage.


Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Osteoarthritis. Early research shows that taking a specific product (AR7 Joint Complex by Robinson Pharma) containing collagen type II, methylsulfonylmethane (MSM), cetyl myristoleate, lipase, vitamin C, turmeric, and bromelain by mouth for 12 weeks reduces joint pain and tenderness in people with osteoarthritis. However, it does not seem to improve X-rays of affected joints.
  • Rheumatoid arthritis (RA). Research on the effects of collagen type II in people with RA shows conflicting results. Some research shows that taking collagen type II by mouth for 3 months reduces joint pain, swelling, and time to walk 15 meters in people with RA. However, other research does not show these improvements when collagen type II is taken for longer periods of time or in higher doses. Also, other research suggests that collagen type II is less effective than the drug methotrexate for treating RA.
  • Pain associated with joint pain after surgery, pain after injury, and back and neck pain.
  • Other conditions.
More evidence is needed to rate the effectiveness of collagen type II for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Collagen type II is POSSIBLY SAFE when taken by mouth in doses up to 2.5 mg daily for up to 24 weeks. It's not clear what the side effects might be. Other collagen products, such as bovine collagen and gelatin, have caused allergic reactions. Since collagen type II contains chondroitin and glucosamine, large doses might lead to the same side effects as those seen with chondroitin and glucosamine supplements. These side effects include nausea, heartburn, diarrhea and constipation, drowsiness, skin reactions, and headache.


Next to red peppers, you can get the most vitamin C from ________________. See Answer

Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking collagen type II if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Egg or chicken allergies: People who are allergic to chicken or eggs should not use collagen type II. Collagen products have been associated with allergic reactions.


The appropriate dose of collagen type II depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for collagen type II. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Health Solutions From Our Sponsors


Buckman K and Gutierrez J, et al. Effects of collagen type II for subjective pain relief. Applied health solutions 1999;

Cathcart, E. S., Hayes, K. C., Gonnerman, W. A., Lazzari, A. A., and Franzblau, C. Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen. Lab Invest 1986;54(1):26-31. View abstract.

Garnero, P., Gineyts, E., Christgau, S., Finck, B., and Delmas, P. D. Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. Arthritis Rheum 2002;46(1):21-30. View abstract.

Garnero, P., Landewe, R., Boers, M., Verhoeven, A., Van Der Linden, S., Christgau, S., Van Der Heijde, D., Boonen, A., and Geusens, P. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study. Arthritis Rheum 2002;46(11):2847-2856. View abstract.

Hauselmann, H. J., Caravatti, M., Seifert, B., Wang, K., Bruckner, P., Stucki, G., and Michel, B. A. Can collagen type II sustain a methotrexate-induced therapeutic effect in patients with long-standing rheumatoid arthritis? A double-blind, randomized trial. Br J Rheumatol 1998;37(10):1110-1117. View abstract.

McKown, K. M., Carbone, L. D., Kaplan, S. B., Aelion, J. A., Lohr, K. M., Cremer, M. A., Bustillo, J., Gonzalez, M., Kaeley, G., Steere, E. L., Somes, G. W., Myers, L. K., Seyer, J. M., Kang, A. H., and Postlethwaite, A. E. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis Rheum 1999;42(6):1204-1208. View abstract.

Nandakumar, K. S., Backlund, J., Vestberg, M., and Holmdahl, R. Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther 2004;6(6):R544-R550. View abstract.

Nissim, A., Winyard, P. G., Corrigall, V., Fatah, R., Perrett, D., Panayi, G., and Chernajovsky, Y. Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint. Arthritis Rheum 2005;52(12):3829-3838. View abstract.

Sewell, K. L. and Trentham, D. E. Pathogenesis of rheumatoid arthritis. Lancet 1-30-1993;341(8840):283-286. View abstract.

Sieper, J and Mitchison, AN. Therapy with oral collagen type II as new possibility for selective immunosuppression in the therapy of rheumatoid arthritis. Zeitschrift fuer Rheumatologie 1994;53(2):53-58.

Trentham DE, Halpner AD, Trentham RA, Bagchi M, Kothari S, Preuss HG, and Bagchi D. Use of undenatured type II collagen in the treatment of rheumatoid arthritis. Clinical Practice of Alternative Medicine 2001;2(4):254-9.

Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., and Weiner, H. L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 9-24-1993;261(5129):1727-1730. View abstract.

Trentham, D. E., Townes, A. S., and Kang, A. H. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 9-1-1977;146(3):857-868. View abstract.

Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Arthritis Rheum 7-15-2008;59(7):905-910. View abstract.

AutoImmune Inc. announces phase III trial results for Colloral. URL (Accessed 24 October 1999).

Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9. View abstract.

Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:623-8. View abstract.

Barnett ML, Kremer JM, St.Clair W, et al. Treatment of rheumatoid arthritis with oral type II collagen. Arthritis Rheum 1998;41:290-7. View abstract.

Kalden JR, Sieper J. Oral collagen in the treatment of rheumatoid arthritis [editorial]. Arthritis Rheum 1998;41:191-4.

Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. View abstract.

Mullins RJ, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Anaphylactic risk for surgeons. Aust N Z J Ophthalmol 1996;24:257-60. View abstract.

Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-36. View abstract.

Xie Q, Shi R, Xu G, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27;7:31. View abstract.