- Least Effective Exercises Slideshow
- Dehydration Tips Slideshow Pictures
- First Aid Sprains & Strains Slideshow Pictures
- Cyclobenzaprine vs. Valium: What's the difference?
- What is cyclobenzaprine? What is Valium?
- What are the side effects of cyclobenzaprine and Valium?
- What is the dosage of cyclobenzaprine vs. Valium?
- What drugs interact with cyclobenzaprine and Valium?
- Are cyclobenzaprine and Valium safe to use while pregnant or breastfeeding?
Cyclobenzaprine vs. Valium: What's the difference?
- Cyclobenzaprine and Valium (diazepam) are used to relieve muscle spasms.
- Cyclobenzaprine is used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions.
- Valium is mainly used to treat anxiety, for sedation during surgery, and for the treatment of agitation, tremors, delirium, seizures, and hallucinations resulting from alcohol withdrawal.
- Brand names for cyclobenzaprine include Flexeril, Amrix, and Fexmid.
- Cyclobenzaprine and Valium belong to different drug classes. Cyclobenzaprine is a muscle relaxant and Valium is a benzodiazepine.
- Side effects of cyclobenzaprine and Valium that are similar include drowsiness, fatigue, vision problems (blurred or double vision), and confusion.
- Side effects of cyclobenzaprine that are different from Valium include dry mouth, headaches, dizziness, nausea, constipation, unpleasant taste, nervousness, acid reflux, and abdominal pain or discomfort.
- Side effects of Valium that are different from cyclobenzaprine include diarrhea, rash, euphoria, loss of balance, excitability, muscle spasm, lack of sleep, rage, and speech problems.
- Withdrawal symptoms may occur if you suddenly stop taking Valium.
What is cyclobenzaprine? What is Valium?
Cyclobenzaprine is a muscle relaxant used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. It is only used short-tem, for up to two or three weeks. Cyclobenzaprine relieves muscle spasm due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Cyclobenzaprine is believed to work through a complex mechanism within the nervous system, likely in the brainstem.
Valium (diazepam) is a benzodiazepine used to treat anxiety. Valium also is used for relief of muscle spasms in some neurological diseases, for sedation during surgery, and for the treatment of agitation, tremors, delirium, seizures, and hallucinations resulting from alcohol withdrawal. Other benzodiazepines also include alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), and flurazepam (Dalmane). Valium and other benzodiazepines act by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders.
What are the side effects of cyclobenzaprine and Valium?
The most common side effects of cyclobenzaprine include:
Other reported side effects include:
- Blurred vision,
- Unpleasant taste
- Acid reflux
- Abdominal pain or discomfort
Possible serious side effects include:
Warning: Diazepam can lead to addiction (dependency), especially when higher dosages are used over prolonged periods of time. In patients addicted to diazepam or after prolonged use, abrupt discontinuation may cause symptoms of withdrawal such as:
Seizures can occur in more severe cases of withdrawal. Therefore, after extended use, diazepam should be slowly tapered under a doctor's supervision rather than abruptly stopped.
The most common side effects of diazepam are:
Other important side effects include:
- Paradoxical reactions with excitability
- Muscle spasm
- Lack of sleep
- Speech problems
- Double vision
Possible serious side effects:
Latest Exercise & Fitness News
Daily Health News
What is the dosage of cyclobenzaprine vs. Valium?
- The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets.
- Diazepam may be taken with or without food.
- Diazepam is disposed of by the liver and excreted mainly by the kidney. Dosages of diazepam may need to be lowered in patients with abnormal kidney function.
- The usual oral diazepam dose for anxiety or seizures is 2-10 mg given 2-4 times daily.
- The usual rectal dose is 0.2-0.5 mg/kg and depends on the age of the patient.
What drugs interact with cyclobenzaprine and Valium?
- Cyclobenzaprine is chemically related to the tricyclic class of antidepressants, for example, amitriptyline (Elavil, Endep), nortriptyline Pamelor). As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together.
- Cyclobenzaprine interacts with other medications and drugs that slow the brain's processes, such as
- benzodiazepines, for example, diazepam (Valium), lorazepam (Ativan), and
Alcohol or medications that cause sedation may add to the sedative effects of diazepam. Patients taking benzodiazepines should avoid such combinations.
The following drugs may prolong the effects of diazepam by inhibiting liver enzymes that eliminate diazepam:
- cimetidine (Tagamet)
- ketoconazole (Nizoral)
- itraconazole (Sporanox)
- omeprazole (Prilosec, Rapinex)
- clarithromycin (Biaxin)
- darunavir (Prezista)
- fluvoxamine (Luvox)
- fluoxetine (Prozac)
Dosages may need to be decreased when these drugs are used with diazepam.
Are cyclobenzaprine and Valium safe to use while pregnant or breastfeeding?
- There are no adequate studies of cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
- It is not known whether cyclobenzaprine is secreted in milk. However, since it is related to the tricyclic antidepressants, some of which are excreted in breast milk, caution is advised in using this medication in women who are breastfeeding.
- Benzodiazepines, including diazepam, can cause fetal abnormalities and should not be used during pregnancy.
- Diazepam is excreted in breast milk and can affect nursing infants. Therefore, diazepam should not be used by women who are nursing.
Cyclobenzaprine and Valium (diazepam) are used to relieve muscle spasms. Cyclobenzaprine is used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. Valium is mainly used to treat anxiety, for sedation during surgery, and for the treatment of agitation, tremors, delirium, seizures, and hallucinations resulting from alcohol withdrawal.
Multimedia: Slideshows, Images & Quizzes
Bodybuilding Pictures: Muscle-Building Workout and Diet for Men
Want bulging biceps and a bigger chest? Our experts demonstrate the right moves to help men build bigger muscles with just two...
Muscle Cramps (Charley Horse) and Muscle Spasms
What are the differences between muscle spasms and cramps? Learn about the causes of muscle spasms and cramps (charley horse) in...
Muscle Cramps: Foods That Help and Prevent Cramping
One way to prevent muscle cramps is to get enough of these nutrients: potassium, sodium, calcium, and magnesium. They’re called...
Picture of Hamstring Muscle
The prominent tendons at the back of the knee. See a picture of Hamstring Muscle and learn more about the health topic.
10 Muscle-Building Exercises for Diabetes
Watch this slideshow on Diabetes and Exercise. If you have diabetes, see how strengthening your muscles with these 10 weight...
Related Disease Conditions
Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing strenuous exercise in a hot environment, prolonged muscle use, and certain diseases of the nervous system may cause muscle spasms. Symptoms and signs of a muscle spasm include an acute onset of pain and a possible bulge seen or felt beneath the skin where the muscle is located. Gently stretching the muscle usually resolves a muscle spasm.
Muscle cramps are involuntarily and forcibly contracted muscles that do not relax. Extremely common, any muscles that have voluntary control, including some organs, are subject to cramp. Since there is such variety in the types of muscle cramps that can occur, many causes and preventative medications are known. Stretching is the most common way to stop or prevent most muscle cramps.
Second Source article from Government
Muscle Pain (Myofascial Pain Syndrome)
Muscle pain (myofascial pain syndrome) is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
Treatment & Diagnosis
- Macrophagic Myofasciitis
- Myositis Muscle (Pain and Inflammation) Serious Drug Interactions
- Progressive Muscle Relaxation
- Is There a Direct Relationship Between Sinusitis and Muscle Pain?
- What Causes Rectal Muscle Spasms?
- What's the Strongest Muscle in the Human Body?
- Can Diabetes Cause Muscle Pain?
- How Muscles Work & Respond to Resistance Training
- Muscle Cramp (Charley Horse) Treatment and Symptoms
Medications & Supplements
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.